Lariam and Halfan
نویسندگان
چکیده
منابع مشابه
A lesson learnt: the rise and fall of Lariam and Halfan.
Lariam (pharmacological name mefloquine) is an antimalaria drug discovered by the US Army shortly after the Vietnam War, and subsequently marketed worldwide by F. Hoffmann-La Roche. The first reported trials of mefloquine were in prisoners, and were performed at the Joliet Correctional Center, Illinois, in 1975, and at the Maryland House of Correction in 1976.1,2 Halfan (pharmacological name ha...
متن کاملEffects of halofantrine hydrochloride (halfan) on the histology of the ovary of mature female Wistar rats.
Halofantrine hydrochloride (halfan) was administered via oral route to matured female wistar rats weighing 180-200 g. The Wistar rats were randomly selected and divided into six groups of four rats each, making a total of twenty four rats and coded A1, A2, A3, B1, B2 and B3. Groups A3 and B3 were used as controls. Three consecutive doses of 1 mg/100 g halfan each were administered to group A1 a...
متن کاملHalofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats
The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg Body not of halofantrine hydrochloride administered orally every six hours for three times (comple...
متن کاملDetermining the absolute configuration of (+)-mefloquine HCl, the side-effect-reducing enantiomer of the antimalaria drug Lariam.
Even though the important antimalaria drug rac-erythro-mefloquine HCl has been on the market as Lariam for decades, the absolute configurations of its enantiomers have not been determined conclusively. This is needed, since the (-) enantiomer is believed to cause adverse side effects in malaria treatment resulting from binding to the adenosine receptor in the human brain. Since there are confli...
متن کاملFluoroquinolones, Piperazines, Lariam, Vite A/D/E as rescue agents, SONAR Citizen’s Petition, Adverse Effects, QVF Library References
s: (there may be repeats in here) Excerpt from: Quinolone Molecular Structure-Activity Relationships: What We Have Learned about Improving Antimicrobial Activity
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 2007
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107680710000806